The vertebrate Kindlins are an evolutionarily conserved family of proteins critical for integrin signalling and cell adhesion. Kindlin-2 (KIND2) is associated with intercalated discs in mice. suggesting a role in cardiac syncytium development; however. deficiency of Kind2 leads to embryonic lethality. https://www.infonoticiasgandia.com/product-category/bottle-stoppers/
Fermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogaster.
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