Mutations in the Autoimmune Regulator (AIRE) gene lead to Autoimmune Polyendocrinopathy Syndrome type 1 (APS1). characterized by the development of multi-organ autoimmune damage. The mechanism by which defects in AIRE result in autoimmunity has been the subject of intense scrutiny. At the cellular level. https://emporiumsmokeshopstles.shop/product-category/pipe-pouches/